2-Piperidineacetic acid, alpha-(4-fluorophenyl)-, methyl ester
CAS number:1354631-33-6

Molecular Formula:

C14H18FNO2
Molecular Weight:

251.3 g/mol
Brief Introduction:

2-Piperidineacetic acid, alpha-(4-fluorophenyl)-, methyl ester (CAS: 1354631-33-6) is a synthetic organic compound. Its structure features a piperidine ring (a six-membered nitrogen-containing heterocycle) substituted at the 2-position with a methyl ester group (–CH₂COOCH₃) and at the alpha position with a 4-fluorophenyl moiety. Key functional groups include a fluorinated aromatic ring, an ester, and an alpha-substituted acetic acid derivative, classifying it as a piperidine-based fluorinated methyl ester. While not widely reported as a registered drug, its structural components—common in CNS-active compounds—suggest potential applications as a pharmaceutical intermediate or research chemical for studying neuropharmacological SAR (e.g., analogs of methylphenidate). Due to its resemblance to controlled substances, regulatory restrictions may apply.

Properities:

Optical Activity	( + / - ) ^[1,2]
Defined Stereocenters	2 / 2 ^[1,2]
E/Z Centers	0 ^[1,2]
Charge	0 ^[1,2]
Additional stereochemistry	No ^[1,2]
Classification Tree	List of designer drugs / Stimulants / Tropanes and Piperidines ^[1]
FDA UNII	TN2LV2C0X9 ^[1]
SMS_ID	300000037361 ^[1]
PUBCHEM	52944002 ^[1].

References:

[1] 4-FLUOROMETHYLPHENIDATE. U.S. Food and Drug Administration.

[2] DESIGNER-DRUGS-LIST. SRS, Mar 21, 2025.

Piperidine derivatives

Contains a six-membered saturated nitrogen-containing heterocycle (piperidine ring).

The aryl group is attached to the alpha position of an acetic acid derivative.

Structurally related to methylphenidate (Ritalin), a central nervous system stimulant.

Used in research contexts for evaluating stimulant or cognitive-enhancing activity.

A world-leading CRO/CDMO company, providing one-stop services from drug discovery to commercial production.

A CRO company focusing on small molecule drug research and development with strong organic synthesis capabilities.

A well-known chemical reagent supplier in China, providing a variety of organic synthesis intermediates.