Bpc 157

CAS number:137525-51-0

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• Molecular Formula:

  C62H98N16O22

• Molecular Weight:

  1419.5 g/mol

• Brief Introduction:

  BPC 157, a stable gastric pentadecapeptide, has garnered significant attention for its diverse therapeutic potential, particularly in promoting tissue healing and recovery across various organ systems. Derived from human gastric juice, BPC 157 has demonstrated remarkable efficacy in accelerating the healing of muscle, tendon, ligament, and bone injuries, as evidenced in multiple animal studies (e.g., Staresinic et al., 2022). Its mechanism of action is multifaceted, involving interactions with the nitric oxide (NO) system, prostaglandins, dopamine, and serotonin pathways, which collectively contribute to its cytoprotective and anti-inflammatory effects (Sikiric et al., 2023). Beyond musculoskeletal injuries, BPC 157 has shown promise in treating gastrointestinal ulcers, vascular disorders, and even neurological conditions, underscoring its broad-spectrum therapeutic applicability (Sikiric et al., 2023; Staresinic et al., 2022). Its stability in gastric juice and lack of significant side effects in clinical trials further enhance its appeal as a potential therapeutic agent (Xu et al., 2020).

• Properities:

  Full Name	Body Protection Compound 157 (BPC 157) [1,2]
  Type	Stable gastric pentadecapeptide [1,2,3]
  Amino Acid Sequence	Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val [2]
  Aliases	PLD-116, PL-10, PL14736, Bepectin [2,3]
  Stability in Gastric Juice	Stable for more than 24 hours [1,2]
  Water Solubility	Stable in water [2]
  Half-life (rats)	~66 hours (male), ~69 hours (female) [1]
  Tmax (i.m., rats)	3 minutes [2]
  Cmax (i.m., rats)	12.3 ng/mL (20 µg/kg), 48.9 ng/mL (100 µg/kg), 141 ng/mL (500 µg/kg) [2].
  Tmax (i.m., dogs)	6.33–8.67 minutes depending on dose [2].
  Cmax (i.m., dogs)	1.05–26.1 ng/mL depending on dose [2].
  Bioavailability (i.m.)	14–19% in rats, 45–51% in dogs [2].
  Tissue Distribution (rats)	High in kidney; also found in skin, intestine, lung, heart, skeletal muscle, liver, spleen, fat, brain (lowest) [2].
  Blood–Brain Barrier Penetration	Low [2].
  Metabolic Degradation	Degraded into six peptide metabolites, some with terminal proline residues [2].

• References:

  [1] Pharmaceuticals 2024, 17, 461 – “The Stable Gastric Pentadecapeptide BPC 157: Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity”

  [2] Pharmaceuticals 2025, 18, 185 – “Multifunctionality and Possible Medical Application of the BPC 157 Peptide—Literature and Patent Review”

  [3] Medical Hypotheses 2022, 158, 110736 – “BPC 157 as Potential Treatment for COVID-19”

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Hubei Weideli Chemical Reagent Co., Ltd.

A modern private enterprise located in Wuhan East Lake New Technology Development Zone, established in 2021, focusing on the research, development, production and sales of scientific research chemical reagents, biochemical raw materials and fine chemical products. Its products cover the fields of medicine, veterinary medicine and agriculture.

Hubei Hongpeptide Biotechnology Co., Ltd.

A high-tech enterprise established in September 2012, focusing on the research and development, production and application of small molecule peptide technology. Headquartered in Wuhan Optical Valley Bio-city, it has a modern industrial base with an annual output of 1,000 tons of small peptides. Its products cover three major fields: medicine, beauty and functional peptides.

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