(-)-Rapamycin
CAS number:53123-88-9
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Molecular Formula:
C51H79NO13
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Molecular Weight:
914.2g/mol
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Brief Introduction:
(-)-Rapamycin, a potent inhibitor of the mammalian target of rapamycin (mTOR), has garnered attention for its significant anti-tumor properties, particularly through its ability to inhibit cancer cell proliferation, block angiogenesis, and induce autophagy. Despite its promising therapeutic effects, its clinical use is often hindered by side effects such as dyslipidemia, metabolic disturbances, and immunosuppression, which can lead to increased susceptibility to infections and reduced overall patient health. In oncology, particularly in breast cancer treatment, combining rapamycin with natural compounds has emerged as a strategy to enhance its therapeutic efficacy while minimizing adverse effects. Notably, recent research has highlighted that the traditional Chinese tea Ilex latifolia can synergize with low-dose rapamycin to significantly boost anti-tumor responses in both in vitro and in vivo breast cancer models, offering a promising complementary approach to conventional therapy.
Macrolide
A class of natural products characterized by a large macrocyclic lactone ring. Rapamycin contains a 31-membered macrolactone ring, classifying it as a macrolide antibiotic.
Polyketide
A group of secondary metabolites produced by polymerization of acetyl and propionyl subunits. It is biosynthesized via a polyketide synthase pathway, typical of many complex natural products from actinomycetes.
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