Midazolam
CAS number:59467-70-8
-
Molecular Formula:
C18H13ClFN3
-
Molecular Weight:
325.8g/mol
-
Brief Introduction:
Midazolam is a short-acting benzodiazepine commonly used for sedation in various medical procedures. In a study examining the effects of midazolam co-administered with oxycodone on ventilation in healthy volunteers, it was found that while midazolam alone did not significantly decrease hypercapnic ventilation compared to placebo, its combination with oxycodone did not further decrease minute ventilation at an end-tidal PCO₂ of 7.3 kPa compared to oxycodone alone. However, midazolam did affect tidal volume, ventilatory frequency, and resting end-tidal PCO₂, suggesting it influences ventilation through relaxation of respiratory muscles. Another study evaluated midazolam combined with fentanyl for sedation during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), finding that the addition of fentanyl to midazolam provided better sedation, with fewer additional sedative requirements and a higher rate of successful procedure completion. In a case report, phenobarbital was used as an alternative treatment for sedative-hypnotic withdrawal syndrome in a patient who had been on prolonged midazolam and other sedative-analgesic infusions, successfully managing withdrawal symptoms and facilitating weaning off sedation.
Benzodiazepines
Midazolam is a member of the benzodiazepine class of drugs. Benzodiazepines are characterized by their core structure, which includes a benzene ring fused to a diazepine ring. This class of drugs is known for their anxiolytic, sedative, hypnotic, anticonvulsant, and muscle relaxant properties.
Sedative-Hypnotics
Midazolam is classified as a sedative-hypnotic agent. These drugs are used to induce and maintain sleep (hypnotic effect) and to produce a state of relaxation and calmness (sedative effect). Midazolam is particularly noted for its rapid onset of action and relatively short duration of effect, making it suitable for short-term sedation and anesthesia induction.
Central Nervous System (CNS) Depressants
Midazolam acts as a CNS depressant by enhancing the effects of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain. This action leads to a reduction in neuronal activity, resulting in sedation, relaxation, and other central nervous system depressant effects.
Anesthetic Agents
Midazolam is used as an anesthetic agent, particularly for premedication and induction of anesthesia. Its rapid onset and short duration of action make it useful for procedures requiring brief periods of unconsciousness.
59467-70-8 Suppliers
Jiangsu Enhua Pharmaceutical Co., Ltd.
Jiangsu Enhua Pharmaceutical Co., Ltd. is a pharmaceutical group company integrating science, industry and trade. It was established on March 27, 1999. The company's main business is the production and sales of central nervous system drug preparations and raw materials. The company's development strategy is positioned in the central nervous system drug market. It is the only company in China's pharmaceutical industry that focuses on the central nervous system drug market segment.
Yichang Renfu Pharmaceutical Co., Ltd.
Yichang Renfu Pharmaceutical Co., Ltd. is a wholly-owned subsidiary of Renfu Pharmaceutical Group and a leading company in the field of anesthetic drugs in China. The company has total assets of 11 billion yuan, more than 7,800 employees, and a market share of over 60% in narcotic drugs. It has recently made major breakthroughs in the research and development of analgesic drugs.
Guangzhou Chemical Reagent Factory
With more than 1200 product varieties and over 3000 specifications, Guangzhou Chemical Reagent Factory serves a wide range of sectors including scientific research institutions, inspection and quarantine services, environmental monitoring, biopharmaceuticals, electronics, electroplating, healthcare, aerospace technology, new energy, and more.
