Disulfiram
CAS number:97-77-8
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Molecular Formula:
C10H20N2S4
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Molecular Weight:
296.5g/mol
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Brief Introduction:
Disulfiram (DSF), originally developed as an anti-alcoholism drug, has drawn attention for its potential in treating various diseases beyond its initial use. According to recent literature, DSF exerts neuroprotective effects by modulating inflammation and redox balance in the brain. In a 2025 study published in Molecules, DSF was evaluated in a rat model of lipopolysaccharide (LPS)-induced neuroinflammation. While it did not improve memory impairment caused by LPS, it significantly increased the level of non-protein thiols (mainly glutathione), suggesting an antioxidative effect that may help mitigate oxidative stress during inflammation. Separately, in cancer research, DSF has been shown to target cancer stem cells (CSCs), particularly in non-small cell lung cancer (NSCLC). It inhibits CSC traits and enhances the cytotoxicity of chemotherapeutic agents when used in combination with copper. However, its clinical application has been limited by a short half-life in the bloodstream. To overcome this, researchers developed a PLGA-nano-encapsulated form of DSF, which showed improved stability and efficacy in both in vitro and in vivo models.
Organosulfur compounds
DSF contains sulfur atoms, specifically in disulfide and thiuram moieties, making it part of the organosulfur family.
Thiuram compounds
Disulfiram is a derivative of thiuram disulfide, characterized by the presence of the (R₂NC(S)S–S) unit.
Carbamodithioates
Disulfiram (DSF) contains two diethyldithiocarbamate groups, a subclass of carbamodithioates.
Prodrugs
DSF is considered a prodrug because it is metabolized in the body to form active compounds, such as diethyldithiocarbamate.
97-77-8 Suppliers
Adisseo
A leading global producer of animal nutrition additives. Its Disulfiram products are known for their high quality and stability and are very popular in the market.
Kingdomway Nutrition,Inc
The main business is the production and sales of nutritional health food raw materials, pharmaceutical raw materials and nutritional health food terminal products. The products are widely used in health food, medical beauty, vitamins and other fields.
Guangzhou Chemical Reagent Factory
With more than 1200 product varieties and over 3000 specifications, Guangzhou Chemical Reagent Factory serves a wide range of sectors including scientific research institutions, inspection and quarantine services, environmental monitoring, biopharmaceuticals, electronics, electroplating, healthcare, aerospace technology, new energy, and more.
